Department
Computer Science and Cybersecurity
Document Type
Poster
Abstract
For population-scale forward genetic studies, experimental errors such as pollen contamination, sample mislabeling, and the presence of siblings in a population of independently mutagenized individuals, can negatively impact the accurate detection of induced causal DNA variants. To mitigate the phenotype to genotype gap we implemented a fast and efficient DNA mutation clustering method for the systematic identification of clusters of likely related mutants in a sequenced population. We demonstrate the utility of the software by the analysis of four large mutant populations. The standalone volvox_scan software is very flexible and has been thoroughly tested on Windows, Mac and Linux platforms.
Publication Date
6-2024
Recommended Citation
Kauffman, C., Ziegler, R., Tursnasazy, B., Helbling, C., Vandermeer, N., & Addo-Quaye, C. (2024, June 22-26). Volvox_scan: Fast detection of related mutants in population-scale forward genetic studies [Poster presentation]. American Society of Plant Biologists Plant Biology Meeting, Honolulu, HI, United States.